The PIM1 antibody - N-terminal region (ARP56389_P050) from Aviva Systems Biology is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Mouse antigen. The PIM1 antibody - N-terminal region (ARP56389_P050) has been validated for the following applications: Western Blot.
Description
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons